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Clinica veterinaria il giglio

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clinica veterinaria il giglio

CLINICA veterinaria LIVE : displasia dell'anca Labrador

2017   the   the

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Increased susceptibility to apoptosis and loss of proper cell cycle control can be observed in lymphocytes from HIV-infected individuals and may contribute to the lymphocyte dysfunction of AIDS patients. To better understand the relation between T-cell activation, apoptosis, and cell cycle perturbation, we studied the effect of exogenous interleukin-2 IL-2 administration on the intracellular turnover of phase-dependent proteins. Circulating T cells from HIV-infected patients display a marked discrepancy between a metabolic profile typical of G 0 and a pattern of expression of phase-dependent proteins that indicates a more-advanced position within the cell cycle. This discrepancy is enhanced by in vitro activation with ConA and ultimately results in a marked increase of apoptotic events. Conversely, treatment of lymphocytes with IL-2 alone restores the phase-specific pattern of expression of cell cycle-dependent proteins and is associated with low levels of apoptosis. Interestingly, exogenous IL-2 administration normalizes the overall intracellular protein turnover, as measured by protein synthesis, half-life of newly synthesised proteins, and total protein ubiquitination, thus providing a possible explanation for the effect of IL-2 on the intracellular kinetics of cell cycle-dependent proteins. Overall these results confirm that perturbation of cell cycle control contributes to HIV-related lymphocyte dysfunction and, by showing that IL-2 administration can revert this perturbation, suggest a new mechanism of action of IL-2 therapy in HIV-infected patients.

Toggle navigation. Microbiologia degli Alimenti. Casa Editrice Ambrosiana Giaccone G. Principi di Microecologia degli alimenti. Zoonosi in Italia nel periodo Parassitologia Veterinaria.



Revista Clinica Veterinaria n. 125

Please note: Google Street View shows an approximate image of the address indicated. The visual may not correspond to the actual view of the property. By: Studio Scivoletto - P.

Clinica Veterinaria Ghiberti - Sesto Fiorentino

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grafico oro tempo reale

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3 COMMENTS

  1. Ansel L. says:







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